Computationally feasible estimation of haplotype frequencies from pooled DNA with and without Hardy-Weinberg equilibrium
نویسندگان
چکیده
منابع مشابه
Forensic DNA tests and Hardy-Weinberg equilibrium.
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متن کاملRegression modeling of allele frequencies and testing Hardy Weinberg Equilibrium.
BACKGROUND/AIMS Tests for whether observed genotype proportions fit Hardy Weinberg Equilibrium (HWE) are widely used in population genetics analyses, as well as to evaluate quality of genotype data. To date, all methods testing for HWE require subjects to be classified into discrete categories, yet it is becoming clear that the distribution of allele frequencies tends to be smooth over geograph...
متن کاملEstimating Haplotype Frequencies from Genotypes of Pooled DNA
Estimating Haplotype Frequencies from Genotypes of Pooled DNA
متن کاملHardy Weinberg Equilibrium Testing and Interpretation: Focus on infection
Hardy-Weinberg equilibrium (HWE) holds when, in a closed population with random mating and without mutation and natural selection, genotype frequencies at any locus is a simple function of allele frequencies. Testing for HWE is now a common practice in population genetics and genetic association studies of non-communicable diseases; however, it is less-regarded, or sometimes miss-interpreted, i...
متن کاملDistributions of Hardy-Weinberg equilibrium test statistics.
It is well established that test statistics and P-values derived from discrete data, such as genetic markers, are also discrete. In most genetic applications, the null distribution for a discrete test statistic is approximated with a continuous distribution, but this approximation may not be reasonable. In some cases using the continuous approximation for the expected null distribution may caus...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2008
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btn623